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Benzodiazepines.

Alprazolam (Xanax) and clonazepam (Klonopin) have been approved by the FDA for the treatment of PD and have been the most extensively studied agents among the benzodiazepines. Alprazolam was found to be superior to placebo in the treatment of panic attacks in both short-term (8-week) and long-term (24-week) RCTs.^140,141 The effective dose range was 3 to 6 mg/day. A sustained-release formulation of alprazolam is also effective in the acute treatment of PD at doses comparable to those of standard alprazolam (mean dose 4.7 mg/day).¹⁴² RCTs of diazepam (Valium) (5 to 20 mg/day),¹⁴³ lorazepam (Ativan) (2 to 8 mg/day),¹⁴⁴ and clonazepam (1 to 4 mg/day)¹⁴⁵ suggest efficacy similar to alprazolam or the TCAs at doses equipotent with alprazolam. Common side effects of benzodiazepines include sedation, ataxia, memory impairment, and withdrawal symptoms. Buy Kalma 2 Alprazolam 2mg online in Australia

Alprazolam in particular has potential for abuse and physical dependence. In an RCT, 35% of the alprazolam-treated group suffered from discontinuation syndrome, compared to 0% of the placebo-treated group.¹⁴⁶ It is generally advised to taper benzodiazepines over a sufficiently prolonged period (at least 8 weeks), especially where high doses are employed.¹⁴⁶ Clinically, benzodiazepines have the advantage of rapid response, and a combination of a benzodiazepine and an antidepressant may potentiate early response compared with antidepressant monotherapy, although clinicians should be alert for possible additive side effects. Buy Kalma 2 Alprazolam 2mg online in Australia

Enhancing Healthcare Team Outcomes

Alprazolam misuse potential comes from its pharmacokinetic properties of a short half-life, rapid absorption, and low lipophilicity. Compared to other benzodiazepines, alprazolam effects may be felt within 30 minutes and can last for about 6 hours. Alprazolam, taken in large doses, produces strong depressive effects, which may cause memory loss. Due to alprazolam’s many adverse effects, the nurse practitioner, a pharmacist, and the primary care provider must educate the patient on how to use the drug[10]: Buy Kalma 2 Alprazolam 2mg online in Australia