Alprazolam (Xanax) 2mg X 50 Tablets

Indications

Alprazolam, known by various trade names, is the most commonly prescribed psychotropic medication in the United States. Alprazolam is frequently prescribed to manage panic and anxiety disorders. Alprazolam has also been subject to misuse for recreational purposes because of its disinhibition, euphoria, and anxiolytic effects. Most of the near-fatal cases with alprazolam are due to polydrug use.[1] Buy Pfizer Xanax 2mg bottle online in Australia

 FDA- labeled Indications

• Anxiety disorders- generalized anxiety disorder
• Panic disorders- with or without agoraphobia
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 Non-FDA-labeled Indications

• Insomnia
• Premenstrual syndrome
• Depression

Mechanism of Action

Alprazolam belongs to a class of psychoactive medications called benzodiazepines. Benzodiazepines bind to the GABA-A receptor. This receptor is made up of five subunits, e.g., alpha, beta, gamma, delta, epsilon, rho, etc. A common GABA-A receptor found in the CNS is made up of two alpha-1 subunits, two beta-2 subunits and one gamma-2 subunit. The benzodiazepine binding site is between the alpha-1 and gamma-2 subunit. Studies in mice suggest that the alpha-1 subunit mediates sedation, amnesia, and ataxic effects of benzodiazepines, and alpha-2 and alpha-3 subunits mediate anxiolytic and muscle-relaxing effects of benzodiazepines. Also, research suggests that BNZ-1 receptors affect sedation and anti-anxiety, while the BNZ-2 affects muscle relaxation, anticonvulsant activity, memory, and motor coordination. Benzodiazepine binding site appear to exhibit coupling with GABA-A receptors, and this enhances the effects of gamma-aminobutyric acid (GABA) by increasing GABA affinity at the GABA-A receptor. The major inhibitory neurotransmitter GABA, when bound to the GABA-A receptor, mediates the calming or inhibitory effects of alprazolam on the human nervous system.[2][3] Buy Pfizer Xanax 2mg bottle online in Australia

Contraindications

Contraindications to alprazolam include patients with known alprazolam or benzodiazepine hypersensitivity or known allergies to any of its components in the drug dosage form. Alprazolam should be avoided if possible by anyone with pulmonary disease. Using alprazolam with CNS depressants, especially opioids, increases the risk of respiratory depression, low blood pressure, and death.[7] Buy Pfizer Xanax 2mg bottle online in Australia

Drug Interactions

Alprazolam is affected by drugs that inhibit or induce CYP3A4. Drugs that are potent inhibitors of CYP3A may lead to an increase in plasma concentrations, which may result in increased adverse events. Medications known to impact alprazolam include azole antifungals (ketoconazole), cimetidine, certain anti-depressants (fluoxetine, fluvoxamine, and nefazodone), macrolide antibiotics (clarithromycin), rifamycins (rifampin), St. John’s wort, seizure medications (carbamazepine, phenytoin), antihistamines and muscle relaxants. Buy Pfizer Xanax 2mg bottle online in Australia